Assessment of coagulation and fibrinolytic factors among patients with type 2 diabetes mellitus in University of Ilorin Teaching Hospital, Ilorin, Nigeria
نویسندگان
چکیده
Diabetes mellitus is characterized by major changes in the coagulation and fibrinolytic system. The study was aimed at assessing degree of system patients with type 2 diabetes North-central Nigeria. This a hospital based comparative Cross-sectional involving 78 diabetics healthy controls. Full blood count performed using Sysmex XP 300 according to manufacturer’s instructions. Prothrombin time determined one stage test Owren. Activated partial thromboplastin method Proctor Rapaport. Fibrinogen assay AssayMax Human ELISA. Plasminogen Activator Inhibitor type-1 PAI-1 ELISA kit. mean age subjects controls were 60.73 ± 10.8 59.65 12.7 years respectively. diastolic pressure significantly higher than that (91.84 11.02 vs 87.58 11.3: p-value =0.002). time, concentration PAI- 1 level (p = 0.047, 0.031 & 0.020). No significant differences observed Platelet count, APTT INR (P=0.938, 0.664 0.059 respectively). confirms cause hypercoagulable state as evidenced alteration There need for proper glycaemic control diabetes.
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ژورنال
عنوان ژورنال: Annals of clinical and biomedical research
سال: 2021
ISSN: ['2724-508X']
DOI: https://doi.org/10.4081/acbr.2021.121